Vol. 5 No. 2 (2021)
Articles

To Evaluate the Protective Effect of Dibenzo-α -Pyrone Derivatives on Indomethacin Induced Ulcer in Wistar Albino Rats

Published 2021-06-30

Abstract

Following standard Hurtley reaction, by using 2-Bromobenzoic acid, resorcinol and NaOH in the presence of CuSO4 solution as a catalyst, a clay coloured solid of Dibenzo-α-pyrone(DBαP) was prepared. This subsequent solid of DBαP was then reacted with various amines respectively, ethanol and formaldehyde are refluxed for 1.5 hours through Mannich reaction resulting into newly synthesized Mannich derivatives of DBαP. The characterization of these compounds were done by various spectral (UV, IR and NMR) and analytical methods. From them, three compounds were selected and further evaluated for antiulcer activity in different in-vivo antiulcer models. Macroscopic evaluations of the gastric mucosa was done. Ulcer Index, Gastric volume and pH level in rats was also done for normal, positive, negative control and 3 selected derivatives. Derivative III was found to be the most potent compound of the series as antiulcer agent.